Urinary 3-(3-Hydroxyphenyl)-3-hydroxypropionic Acid, 3-Hydroxyphenylacetic Acid, and 3-Hydroxyhippuric Acid Are Elevated in Children with Autism Spectrum Disorders

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Urinary 3-(3-Hydroxyphenyl)-3-hydroxypropionic Acid, 3-Hydroxyphenylacetic Acid, and 3-Hydroxyhippuric Acid Are Elevated in Children with Autism Spectrum Disorders

Autism spectrum disorders (ASDs) are a group of mental illnesses highly correlated with gut microbiota. Recent studies have shown that some abnormal aromatic metabolites in autism patients are presumably derived from overgrown Clostridium species in gut, which may be used for diagnostic purposes. In this paper, a GC/MS based metabolomic approach was utilized to seek similar biomarkers by analyz...

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Homovanillic acid is an important metabolite of dopamine, and a high proportion of patients with neuroblastoma excrete increased amounts of it in their urine. When this diagnosis is suspected, both homovanillic acid and vanilmandelic acid should be measured, because such a combined measurement reportedly leads to detection of 95% of cases. Although rapid and reliable chemical methods are availa...

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BACKGROUND 3-Hydroxypropionic acid (3-HP) is an important platform chemical that boasts a variety of industrial applications. Gene expression systems inducible by 3-HP, if available, are of great utility for optimization of the pathways of 3-HP production and excretion. RESULTS Here we report the presence of unique inducible gene expression systems in Pseudomonas denitrificans and other micro...

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The crystal structure of the title compound, C(11)H(12)O(2), consists of dimers which are formed due to inter-molecular O-H⋯O hydrogen bonding. The dimers are linked to each other by C-H⋯O hydrogen bonds, where C-H belongs to the benzene ring and the O atom is of a carbonyl group of an adjoining mol-ecule. There exist two inter-molecular C-H⋯O hydrogen bonds which form five-membered rings. Ther...

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ژورنال

عنوان ژورنال: BioMed Research International

سال: 2016

ISSN: 2314-6133,2314-6141

DOI: 10.1155/2016/9485412